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KMID : 0360220180590050403
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Journal of the Korean Ophthalmological Society
2018 Volume.59 No. 5 p.403 ~ p.409
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The Effect of 5% Serum Albumin on Intractable Corneal Epithelial Keratitis: a Case Series and Literature Review
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Hwang You-Sook
Cho Yang-Kyung
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Abstract
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Purpose: We report five cases of intractable epithelial keratitis in which 5% serum albumin showed significant effects as a topical treatment when compared with other previous conservative treatments based on a literature review.
Methods: This was a retrospective observational case series of five patients with intractable corneal epithelial keratitis who used serum albumin as a topical treatment. All patients had already been using other conservative treatments such as non-preserved artificial tears and autologous serum eye drops. The size of the epithelial defect and the time taken for closure of the epithelial defect were observed.
Results: The study involved five patients with intractable corneal epithelial disease with a mean follow-up time of 6 months. The epithelial lesions improved with the use of 5% serum albumin from the beginning of treatment and lasted throughout the follow-up period. The mean time to complete epithelial closure using 5% serum albumin eye drops was 21 days.
Conclusions: Treatment with 5% serum albumin eye drops may have a significant and stable effect in the treatment of intractable corneal epithelial disease.
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KEYWORD
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Intractable corneal epithelial keratitis, Serum albumin eye drop
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